top of page

Exposing pregnant mice to cigarette smoke hurt newborns' heart-healing abilities


photo of a pregnant holding cigarette
(nd3000, EnvatoElements)

Exposure to cigarette smoke in utero strongly harms a newborn heart's ability to repair itself after injury, according to a preliminary study of mice.


Findings in animals may not translate to humans, but researchers of the new study hope it helps scientists advance their understanding of possible regeneration in adult human hearts. They presented their findings this week at the American Heart Association's Basic Cardiovascular Sciences conference in Boston.

Past studies have shown neonatal mice in the first week of life can regenerate their hearts after an injury, including heart attack. While that possibility for human babies is still not fully understood, some anecdotal reports suggest the neonatal human heart also may be able to regenerate after injury.


For the new study, Stanford University researchers exposed one group of pregnant mice to cigarette smoke every day throughout pregnancy. The other group of mice breathed filtered air. Two days after birth, mice pups from each group were given a surgically induced heart attack. Researchers analyzed their cardiac function and tissue to see how the smoke impacted the heart's ability to repair itself.


The study found that exposing mice to daily cigarette smoke in utero "significantly compromised" cardiac regeneration, compared to the mice who breathed nothing but filtered air. The finding could have implications for humans, especially pregnant women who smoke, said Katharina Schimmel, the study's lead author.


According to the Centers for Disease Control and Prevention, 7.2% of women who gave birth in 2016 smoked cigarettes during pregnancy.


"The high number of women smoking while pregnant is shocking, and if this study is translatable to humans, it reinforces the importance of smoking cessation during pregnancy," said Schimmel, a postdoctoral research fellow at Stanford."


"This study suggests that maternal exposure to cigarette smoke may affect the heart in surprising ways. In addition, understanding how this happens could shed light on the mystery of why adult humans can't regenerate damaged heart tissue," said Dr. Richard T. Lee, a professor of stem cell and regenerative biology at Harvard University. Lee was not involved in the study.


Schimmel said researchers are still in the early stages of solving the riddle of why neonatal mammal hearts regenerate, while adult ones don't.


"It's really difficult in the lab to specifically pinpoint pathways that are important for cardiac regeneration," she said. "If you compare a (heart attack) in a newborn mouse with one in an adult mouse, you will find a lot of cellular factors changed that may or may not be related to cardiac regeneration."


She said the study broke new ground by being one of the first of its kind to successfully use highly-sensitive strain imaging echocardiography on newborn mice. She also said the study results are "an important first step" in identifying the cellular processes that take place as newborn mammal hearts regenerate after an injury.


Her group is conducting further research to figure out exactly when and how, the regeneration process stalled in the newborn mice that were exposed to smoke.


"We are hoping to finally be able to pinpoint cellular pathways that are essential for cardiac regeneration," she said. "Our hope is that one day, the adult heart could also recover after suffering a heart attack."


Source:

9 Comments


unknownytube
Feb 24

Click here provide members with discounts on over-the-counter medications, vitamins, and health essentials, promoting better health management and cost-effective wellness solutions. kaiserotcbenefits.com - more details here


Click here help you find recent death notices, providing information about funeral services, memorials, and tributes for loved ones in your area. obituariesnearme.com - more details here


Click here? Many users have had mixed experiences with the platform, so it's important to read reviews and verify deals before booking. istravelurolegit.com - more details here

Like

BFVY IRTO
BFVY IRTO
Jan 07

代发外链 提权重点击找我;

蜘蛛池 蜘蛛池;

谷歌马甲包/ 谷歌马甲包;

谷歌霸屏 谷歌霸屏;

谷歌霸屏 谷歌霸屏

蜘蛛池 蜘蛛池

谷歌快排 谷歌快排

Google外链 Google外链

谷歌留痕 谷歌留痕

Gái Gọi…

Gái Gọi…

Dịch Vụ…

谷歌霸屏 谷歌霸屏

负面删除 负面删除

币圈推广 币圈推广

Google权重提升 Google权重提升

Google外链 Google外链

google留痕 google留痕

Like

BFVY IRTO
BFVY IRTO
Dec 25, 2024

代发外链 提权重点击找我;

游戏推广 游戏推广;

Fortune Tiger Fortune Tiger;

Fortune Tiger Slots Fortune…

谷歌马甲包/ 谷歌马甲包;

谷歌霸屏 谷歌霸屏;

מכונות ETPU מכונות ETPU;

;ماكينات اي تي بي…

آلات إي بي بي…

ETPU maşınları ETPU maşınları;

ETPUマシン ETPUマシン;

ETPU 기계 ETPU 기계;

Like

WKDU TRBD
WKDU TRBD
Dec 19, 2024

google seo google seo技术飞机TG-cheng716051;

03topgame 03topgame

gamesimes gamesimes;

Fortune Tiger Fortune Tiger;

Fortune Tiger Slots Fortune Tiger…

Fortune Tiger Fortune Tiger;

EPS машины EPS машины;

Fortune Tiger Fortune Tiger;

EPS Machine EPS Cutting Machine;

EPS Machine EPS and EPP…

EPP Machine EPP Shape Moulding…

EPS Machine EPS and EPP…

EPTU Machine ETPU Moulding Machine

EPS Machine EPS Cutting Machine;

Like

WKDU TRBD
WKDU TRBD
Dec 17, 2024
Like

554 Boston Post Rd. Unit 1, Milford, CT 06460

12443 San Jose Blvd, Suite 303, Jacksonvillle, FL 32223

1136 Route 22 West. Suite 103, Mountainside, NJ 07092

3 West Main Street, Suite 208, Elmsford, NY 10523

171 Market Square, Suite 201, Newington, CT 06111

4 North Washington Ave. Bergenfield, NJ 07621

Wingren Plaza, 4225 Wingren Dr. Suite 210, Irving, TX 75062

147 West Merrick Road, 2F, 

Freeport, NY 11520

71 East Avenue, Suite T, Norwalk,  CT 06460

658 Newark Avenue,  Jersey City NJ 07306

5835 Callaghan Road, Suite 601, San Antonio, TX 78228

224-15 Union Turnpike, 2F, Oakland Gardens, NY 11364

2531 NW 41st. Street Bldg B, Gainesville, FL 32606

513 W Mt. Pleasant Ave. Suite 222, Livingston, NJ 07039

2171 Jericho Turnpike, Suite 195, Commack, NY 11725

W.Springfield, Massachusetts

181 Park Avenue, Suite 8,

West Springfield, MA 01089

Our Client Reviews

  • Facebook - Black Circle
  • Twitter - Black Circle
  • Google+ - Black Circle
  • YouTube - Black Circle
  • Pinterest - Black Circle
  • Instagram - Black Circle

HealthForce Training Center provides high-quality training and the latest American Heart Association programs customized for health and non-healthcare providers. Our mission is to provide a fun and stress-free learning experience that can equip individuals with the knowledge and skills to be confident with their medical care and emergency situations.

AHA Disclaimer: The American Heart Association strongly promotes knowledge and proficiency in BLS, ACLS, and PALS and has developed instructional materials for this purpose. Use of these materials in an educational course does not represent course sponsorship by the American Heart Association. Any fees charged for such a course, except for a portion of fees needed for AHA materials, do not represent income to the Association.

American Hearth Association
United States Flag icon
email icon
phone icon
1-866-CPR-9593
1-866-277-9593
debit/credit cards

© 2024 Synergy Healthcare International |Healthforce Training Center
 

bottom of page